{"id":444,"date":"2023-01-24T17:55:00","date_gmt":"2023-01-24T17:55:00","guid":{"rendered":"https:\/\/accelyspharma.com\/?p=444"},"modified":"2025-06-12T17:57:25","modified_gmt":"2025-06-12T17:57:25","slug":"%e3%82%a2%e3%82%ad%e3%83%a5%e3%83%aa%e3%82%b9%e3%83%95%e3%82%a1%e3%83%bc%e3%83%9e%e3%81%8cpitolisant%e3%81%ae%e9%96%89%e5%a1%9e%e6%80%a7%e7%9d%a1%e7%9c%a0%e6%99%82%e7%84%a1%e5%91%bc%e5%90%b8%e7%97%87","status":"publish","type":"post","link":"https:\/\/accelyspharma.com\/ja\/%e3%82%a2%e3%82%ad%e3%83%a5%e3%83%aa%e3%82%b9%e3%83%95%e3%82%a1%e3%83%bc%e3%83%9e%e3%81%8cpitolisant%e3%81%ae%e9%96%89%e5%a1%9e%e6%80%a7%e7%9d%a1%e7%9c%a0%e6%99%82%e7%84%a1%e5%91%bc%e5%90%b8%e7%97%87\/","title":{"rendered":"\u30a2\u30ad\u30e5\u30ea\u30b9\u30d5\u30a1\u30fc\u30de\u304cpitolisant\u306e\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\u306b\u4f34\u3046 \u65e5\u4e2d\u306e\u904e\u5ea6\u306e\u7720\u6c17\u306b\u5bfe\u3059\u308b\u56fd\u5185\u7b2c3\u76f8\u81e8\u5e8a\u8a66\u9a13\u3092\u958b\u59cb"},"content":{"rendered":"\t\t
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\u795e\u7d4c\u30fb\u7cbe\u795e\u75be\u60a3\u9818\u57df\u306b\u304a\u3051\u308b\u9769\u65b0\u7684\u306a\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3068\u5546\u696d\u5316\u3092\u63a8\u9032\u3059\u308b\u88fd\u85ac\u30d9\u30f3\u30c1\u30e3\u30fc\u4f01\u696d\u3067\u3042\u308b\u30a2\u30ad\u30e5\u30ea\u30b9\u30d5\u30a1\u30fc\u30de\u682a\u5f0f\u4f1a\u793e\uff08\u672c\u793e\uff1a\u6771\u4eac\u90fd\u6e2f\u533a\u3001\u4ee3\u8868\u53d6\u7de0\u5f79\u793e\u9577\u517cCEO\uff1a\u7db1\u5834 \u4e00\u6210\u3001\u4ee5\u4e0b\u300c\u30a2\u30ad\u30e5\u30ea\u30b9\u30d5\u30a1\u30fc\u30de\u300d\uff09\u306f\u3001\u30d2\u30b9\u30bf\u30df\u30f3H3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\/\u9006\u4f5c\u52d5\u85acpitolisant\uff08\u4ee5\u4e0b\u672c\u5264\uff09\u306b\u3064\u3044\u3066\u3001\u6301\u7d9a\u967d\u5727\u547c\u5438\uff08CPAP\uff09\u7642\u6cd5\u306b\u3088\u308b\u6cbb\u7642\u3092\u884c\u3063\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\uff08OSAS\uff09\u306b\u4f34\u3046\u65e5\u4e2d\u306e\u904e\u5ea6\u306e\u7720\u6c17\u304c\u6b8b\u5b58\u3059\u308b\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u56fd\u5185\u7b2c3\u76f8\u81e8\u5e8a\u8a66\u9a13\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u306e\u3067\u304a\u77e5\u3089\u305b\u3057\u307e\u3059\u3002<\/p>

\u672c\u8a66\u9a13\u306f\u3001\u591a\u65bd\u8a2d\u5171\u540c\u3001\u7121\u4f5c\u70ba\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u3001\u4e26\u884c\u7fa4\u9593\u6bd4\u8f03\u8a66\u9a13\uff08\u30d1\u30fc\u30c81\uff09\u3068\u3001\u305d\u306e\u5f8c\u306e\u591a\u65bd\u8a2d\u5171\u540c\u3001\u975e\u76f2\u691c\u3001\u9577\u671f\u7d99\u7d9a\u6295\u4e0e\u8a66\u9a13\uff08\u30d1\u30fc\u30c82\uff09\u304b\u3089\u306a\u308b\u65e5\u672c\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u56fd\u5185\u7b2c3\u76f8\u8a66\u9a13\u3067\u3001\u672c\u5264\u306e\u6709\u52b9\u6027\u53ca\u3073\u5b89\u5168\u6027\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>

\u203b\u672c\u8a66\u9a13\u306e\u8a73\u7d30\u306f\u3001\u4ee5\u4e0b\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002
URL\uff1ahttps:\/\/jrct.niph.go.jp\/latest-detail\/jRCT2031220501<\/a><\/p>

\u672c\u5264\u306fBioprojet\u793e\uff08\u30d5\u30e9\u30f3\u30b9\u3001\u30d1\u30ea\u5e02\uff09\u304c\u958b\u767a\u3057\u3001\u5f53\u793e\u304c\u65e5\u672c\u3067\u306e\u72ec\u5360\u7684\u958b\u767a\u30fb\u5546\u696d\u5316\u306b\u95a2\u3059\u308b\u30e9\u30a4\u30bb\u30f3\u30b9\u3092\u6709\u3057\u3001\u73fe\u5728\u3001\u65e5\u672c\u306b\u304a\u3051\u308b\u672c\u5264\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002Pitolisant\u306f\u3001\u6b27\u5dde\u3067\u306f2021\u5e74\u306b\u300c\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\uff08OSAS\uff09\u60a3\u8005\u306b\u304a\u3051\u308b\u899a\u9192\u72b6\u614b\u306e\u6539\u5584\u53ca\u3073\u65e5\u4e2d\u306e\u904e\u5ea6\u306e\u7720\u6c17\u306e\u6e1b\u5c11\u300d\u3092\u52b9\u80fd\u30fb\u52b9\u679c\u3068\u3057\u3066\u6b27\u5dde\u533b\u85ac\u54c1\u5e81\uff08EMA\uff09\u3088\u308a\u627f\u8a8d\u53d6\u5f97\u3057\u3066\u304a\u308a\u3001\u65e2\u306b\u81e8\u5e8a\u73fe\u5834\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>

OSAS\u306f\u3001\u7761\u7720\u4e2d\u306b\u4e0a\u6c17\u9053\u306e\u72ed\u7a84\u30fb\u9589\u585e\u304c\u751f\u3058\u308b\u305f\u3081\u306b\u9069\u5207\u306a\u547c\u5438\u304c\u59a8\u3052\u3089\u308c\u308b\u75be\u60a3\u3067\u3001\u4ee3\u8868\u7684\u306a\u75c7\u72b6\u306b\u306f\u3001\u5927\u304d\u306a\u3044\u3073\u304d\u3001\u65e5\u4e2d\u306e\u7720\u6c17\u3001\u4e0d\u7720\u3001\u719f\u7761\u611f\u306e\u6b20\u5982\u3001\u5168\u8eab\u306e\u5026\u6020\u611f\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u9069\u5207\u306a\u6cbb\u7642\u304c\u884c\u308f\u308c\u306a\u3044\u5834\u5408\u306e\u4e2d\u9577\u671f\u7684\u306a\u554f\u984c\u3068\u3057\u3066\u3001\u9ad8\u8840\u5727\u3084\u52d5\u8108\u786c\u5316\u306a\u3069\u306e\u5faa\u74b0\u5668\u7cfb\u75be\u60a3\u3001\u7cd6\u5c3f\u75c5\u3001\u3046\u3064\u75c5\u306a\u3069\u306e\u5408\u4f75\u75c7\u30ea\u30b9\u30af\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u00a01,2<\/sup>\u3002<\/p>

OSAS\u306e\u6a19\u6e96\u7684\u306a\u6cbb\u7642\u6cd5\u3067\u3042\u308bCPAP\uff08Continuous Positive Airway Pressure\uff09\u306f\u3001\u4e0a\u6c17\u9053\u306e\u72ed\u7a84\u30fb\u9589\u585e\u3092\u7de9\u548c\u3057\u3001OSAS\u306b\u4f34\u3046\u8af8\u75c7\u72b6\u3084\u751f\u6d3b\u306e\u8cea\uff08QOL\uff09\u306e\u6539\u5584\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3055\u3093\u306b\u304a\u3044\u3066\u306f\u9069\u5207\u306a\u57fa\u672c\u6cbb\u7642\u306b\u3082\u95a2\u308f\u3089\u305a\u6b8b\u5b58\u3059\u308b\u7720\u6c17\u304c\u7d99\u7d9a\u3059\u308b\u5834\u5408\u3082\u3042\u308a3<\/sup>\u3001\u65e5\u4e2d\u306e\u904e\u5ea6\u306a\u7720\u6c17\u306f\u3001\u52b4\u50cd\u751f\u7523\u6027\u3078\u306e\u5f71\u97ff\u3001QOL\u306e\u4f4e\u4e0b\u3001\u4ea4\u901a\u4e8b\u6545\u306a\u3069\u306e\u4e8b\u6545\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3055\u308c\u3066\u3044\u308b4<\/sup>\u3053\u3068\u304b\u3089\u3001\u65b0\u305f\u306a\u6cbb\u7642\u9078\u629e\u80a2\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>

\u30a2\u30ad\u30e5\u30ea\u30b9\u30d5\u30a1\u30fc\u30de\u306f\u3001\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\u3092\u62b1\u3048\u308b\u60a3\u8005\u3055\u3093\u3001\u305d\u306e\u3054\u5bb6\u65cf\u304c\u3088\u308a\u5b89\u5fc3\u3057\u3066\u3001\u81ea\u5206\u3089\u3057\u304f\u751f\u6d3b\u3067\u304d\u308b\u793e\u4f1a\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u3001\u672c\u5264\u3092\u65e5\u672c\u306e\u60a3\u8005\u3055\u3093\u3078\u4e00\u65e5\u3082\u65e9\u304f\u5c4a\u3051\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3001\u4e8b\u696d\u3092\u63a8\u9032\u3057\u3066\u53c2\u308a\u307e\u3059\u3002<\/p>

\u00a0<\/p>

Pitolisant\u306b\u3064\u3044\u3066<\/h3>

Pitolisant\u306f\u3001\u4eba\u9593\u306e\u7761\u7720\u30fb\u899a\u9192\u30ea\u30ba\u30e0\u306e\u5236\u5fa1\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u30d2\u30b9\u30bf\u30df\u30f3\u542b\u6709\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u30b7\u30ca\u30d7\u30b9\u524d\u90e8\u306b\u5206\u5e03\u3059\u308b\u81ea\u5df1\u53d7\u5bb9\u4f53\u3001\u30d2\u30b9\u30bf\u30df\u30f3H3\u53d7\u5bb9\u4f53\u3078\u9078\u629e\u7684\u306b\u7d50\u5408\u3059\u308b\u62ee\u6297\u85ac\/\u9006\u4f5c\u52d5\u85ac\u3067\u3059\u3002pitolisant\u306f\u3001Bioprojet\uff08\u30d5\u30e9\u30f3\u30b9\u3001\u30d1\u30ea\u5e02\uff09\u306b\u3088\u308a\u5275\u85ac\u3055\u308c\u3001\u6b27\u5dde\u3067\u306f2016\u5e74\u306b\u300c\u30ab\u30bf\u30d7\u30ec\u30ad\u30b7\u30fc\uff08\u60c5\u52d5\u8131\u529b\u767a\u4f5c\uff09\u3092\u4f34\u3046\u3001\u53c8\u306f\u4f34\u308f\u306a\u3044\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u300d\u3092\u52b9\u80fd\u30fb\u52b9\u679c\u3068\u3057\u3066\u30012021\u5e74\u306b\u306f\u300c\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\uff08OSAS\uff09\u60a3\u8005\u306b\u304a\u3051\u308b\u899a\u9192\u72b6\u614b\u306e\u6539\u5584\u53ca\u3073\u65e5\u4e2d\u306e\u904e\u5ea6\u306e\u7720\u6c17\u306e\u6e1b\u5c11\u300d\u3092\u8ffd\u52a0\u306e\u52b9\u80fd\u30fb\u52b9\u679c\u3068\u3057\u3066\u6b27\u5dde\u533b\u85ac\u54c1\u5e81\uff08EMA\uff09\u3088\u308a\u627f\u8a8d\u53d6\u5f97\u3057\u307e\u3057\u305f\u3002\u7c73\u56fd\u3067\u306f2019\u5e74\u306b\u300c\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u306b\u4f34\u3046\u65e5\u4e2d\u306e\u904e\u5ea6\u306e\u7720\u6c17\u300d\u3092\u52b9\u80fd\u30fb\u52b9\u679c\u3068\u3057\u3066\u30012020\u5e74\u306b\u306f\u300c\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u306b\u4f34\u3046\u30ab\u30bf\u30d7\u30ec\u30ad\u30b7\u30fc\u300d\u3092\u8ffd\u52a0\u306e\u52b9\u80fd\u30fb\u52b9\u679c\u3068\u3057\u3066\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u3088\u308a\u627f\u8a8d\u3092\u53d6\u5f97\u3057\u3066\u3044\u307e\u3059\u3002<\/p>

\u00a0<\/p>

\u30a2\u30ad\u30e5\u30ea\u30b9\u30d5\u30a1\u30fc\u30de\u682a\u5f0f\u4f1a\u793e\u306b\u3064\u3044\u3066<\/h3>

\u30a2\u30ad\u30e5\u30ea\u30b9\u30d5\u30a1\u30fc\u30de\u682a\u5f0f\u4f1a\u793e\u306f\u201cCatalyst to Access\u201d\uff08\u9769\u65b0\u7684\u306a\u533b\u7642\u3078\u306e\u6a4b\u6e21\u3057\u3092\u62c5\u3046\uff09\u3068\u3044\u3046\u7406\u5ff5\u304b\u3089\u5275\u3089\u308c\u305fAculys\u3092\u793e\u540d\u3068\u3059\u308b\u65e5\u672c\u767a\u306e\u88fd\u85ac\u30d9\u30f3\u30c1\u30e3\u30fc\u4f01\u696d\u3067\u3059\u3002\u795e\u7d4c\u30fb\u7cbe\u795e\u75be\u60a3\u9818\u57df\u306b\u304a\u3044\u3066\u9769\u65b0\u7684\u306a\u533b\u7642\u624b\u6bb5\u3078\u306e\u6a4b\u6e21\u3057\u5f79\u3068\u306a\u308a\u3001\u60a3\u8005\u3055\u3093\u3068\u3054\u5bb6\u65cf\u3001\u533b\u7642\u95a2\u4fc2\u8005\u3001\u793e\u4f1a\u306b\u3088\u308a\u826f\u3044\u533b\u7642\u3092\u5c4a\u3051\u308b\u305f\u3081\u3001\u6b27\u7c73\u8af8\u56fd\u304b\u3089\u9769\u65b0\u7684\u3067\u512a\u308c\u305f\u533b\u85ac\u54c1\u3092\u5c0e\u5165\u3057\u3001\u958b\u767a\u30fb\u8ca9\u58f2\u3092\u62c5\u3044\u3001\u3055\u3089\u306b\u75be\u60a3\u3092\u53d6\u308a\u5dfb\u304f\u3055\u307e\u3056\u307e\u306a\u8ab2\u984c\u306b\u5bfe\u3059\u308b\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>

\u4f1a\u793e\u540d\uff1a\u30a2\u30ad\u30e5\u30ea\u30b9\u30d5\u30a1\u30fc\u30de\u682a\u5f0f\u4f1a\u793e \uff3b\u82f1\u8a9e\u540d\uff1aAculys Pharma, Inc. \uff3d
\u6240\u5728\u5730\uff1a\u6771\u4eac\u90fd\u6e2f\u533a\u5317\u9752\u5c712 -14 \u2013 4
\u4ee3\u8868\u8005\uff1a\u7db1\u5834 \u4e00\u6210
\u8a2d\u7acb\u65e5\uff1a2021\u5e741\u6708
URL\uff1ahttps:\/\/aculys.com<\/a><\/p>

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\u672c\u30ea\u30ea\u30fc\u30b9\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u533b\u85ac\u54c1\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u5f53\u793e\u306e\u7d4c\u55b6\u60c5\u5831\u306e\u958b\u793a\u3092\u76ee\u7684\u3068\u3057\u3066\u304a\u308a\u3001\u5f53\u8a72\u533b\u85ac\u54c1\u306e\u5ba3\u4f1d\u30fb\u5e83\u544a\u3092\u76ee\u7684\u3068\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>

1. \u65e5\u672c\u5faa\u74b0\u5668\u5b66\u4f1a\uff0e\u5faa\u74b0\u5668\u75c5\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff082008-2009\u5e74\u5ea6\u5408\u540c\u7814\u7a76\u73ed\u5831\u544a\uff09\u5faa\u74b0\u5668\u9818\u57df\u306b\u304a\u3051\u308b\u7761\u7720\u547c\u5438\u969c\u5bb3\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff0e2. \u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\uff08SAS\uff09\u306e\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u4f5c\u6210\u59d4\u54e1\u4f1a\uff08\u7de8\uff09\uff1a\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\uff08SAS\uff09\u306e\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f320203. Update on Persistent Excessive Daytime Sleepiness in OSA; Chest . 2020 Aug;158(2):776-786.4. The economic and societal burden of excessive daytime sleepiness in patients with obstructive sleep apnea. Sleep Med Rev. 2020 Jun;51:101275.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

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